4-(Chloromethyl)-2-(4-fluorophenyl)-5-methyl-1,3-oxazole → HCID 10432356, compound

HRID 2181211Notes

Reaction equation

HRID 2181211 reaction equation
C([O:3][C:4](=[O:19])[CH:5]([O:16][CH2:17][CH3:18])[CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[CH:10]2)C.Cl[CH2:21][C:22]1[N:23]=[C:24]([C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)[O:25][C:26]=1[CH3:27]>>[CH2:17]([O:16][CH:5]([CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH2:21][C:22]1[N:23]=[C:24]([C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)[O:25][C:26]=1[CH3:27])[CH:11]=[CH:10]2)[C:4]([OH:3])=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 106092554-(Chloromethyl)-2-(4-fluorophenyl)-5-methyl-1,3-oxazoleHCID 69563293Rac-2-ethoxy-3-(1h-indol-5-yl)-propionic acid ethyl ester

Product 1

HCID 10432356HCID 10432356, compoundYield 39%

Procedure

Starting from rac-2-ethoxy-3-(1H-indol-5-yl)-propionic acid ethyl ester and 4-chloromethyl-2-(4-fluoro-phenyl)-5-methyl-oxazole, the title compound was obtained in 39% yield as a colourless solid. MS: (M+H)30 423.3.

Sources & evidence

ORD record
ord-d7bee7d3a8944a9896d4b33605eb829a
Source dataset
uspto-grants-2005_05
Patent number
US06890947B2

Reaction notes

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