Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl- → HCID 10412116, compound

HRID 2181215Notes

Reaction equation

HRID 2181215 reaction equation
C([O:3][C:4](=[O:19])[CH:5]([O:16][CH2:17][CH3:18])[CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[CH:10]2)C.Cl[CH2:21][C:22]1[N:23]=[C:24]([C:28]2[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[C:30]([O:36][CH3:37])[CH:29]=2)[O:25][C:26]=1[CH3:27]>>[CH3:37][O:36][C:30]1[CH:29]=[C:28]([C:24]2[O:25][C:26]([CH3:27])=[C:22]([CH2:21][N:12]3[C:13]4[C:9](=[CH:8][C:7]([CH2:6][CH:5]([O:16][CH2:17][CH3:18])[C:4]([OH:3])=[O:19])=[CH:15][CH:14]=4)[CH:10]=[CH:11]3)[N:23]=2)[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=1

Participants

3

Reactant 2

HCID 21974252Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl-HCID 69563293Rac-2-ethoxy-3-(1h-indol-5-yl)-propionic acid ethyl ester

Product 1

HCID 10412116HCID 10412116, compoundYield 50%

Procedure

Starting from rac-2-ethoxy-3-(1H-indol-5-yl)-propionic acid ethyl ester and 4-chloromethyl-2-(3,5-dimethoxy-phenyl)-5-methyl-oxazole, the title compound was obtained in 50% yield as a colourless solid. MS: (M−H)− 463.2.

Sources & evidence

ORD record
ord-275d1989e5bd416e8bd583fd034e4256
Source dataset
uspto-grants-2005_05
Patent number
US06890947B2

Reaction notes

Loading…