Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl- → (S)-3-{1-[2-(3,5-Dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-2-ethoxy-propionic Acid

HRID 2181216Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2181216
C[O:2][C:3](=[O:18])[C@@H:4]([O:15][CH2:16][CH3:17])[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[CH:9]2.Cl[CH2:20][C:21]1[N:22]=[C:23]([C:27]2[CH:32]=[C:31]([O:33][CH3:34])[CH:30]=[C:29]([O:35][CH3:36])[CH:28]=2)[O:24][C:25]=1[CH3:26]>>[CH3:36][O:35][C:29]1[CH:28]=[C:27]([C:23]2[O:24][C:25]([CH3:26])=[C:21]([CH2:20][N:11]3[C:12]4[C:8](=[CH:7][C:6]([CH2:5][C@H:4]([O:15][CH2:16][CH3:17])[C:3]([OH:2])=[O:18])=[CH:14][CH:13]=4)[CH:9]=[CH:10]3)[N:22]=2)[CH:32]=[C:31]([O:33][CH3:34])[CH:30]=1

Komponenten

3

Edukt 2

HCID 21974252Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl-HCID 69563912(S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester

Produkt 1

HCID 10457157(S)-3-{1-[2-(3,5-Dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-2-ethoxy-propionic AcidAusbeute 43 %

Versuchsvorschrift

Starting from (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester and 4-chloromethyl-2-(3,5-dimethoxy-phenyl)-5-methyl-oxazole, the title compound was obtained in 43% yield as a pale red solid. MS: (M−H)− 463.2.

Quellen und Nachweise

ORD-Eintrag
ord-3360ffa6993f4a00a9f941ae118da88f
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06890947B2

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