HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl- → (S)-3-{1-[2-(3,5-Dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-2-ethoxy-propionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl- | HCID 21974252 | — |
| Reactant | (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester | HCID 69563912 | — |
| Product | (S)-3-{1-[2-(3,5-Dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-2-ethoxy-propionic Acid | HCID 10457157 | 43% |
Reaction Steps
Starting from (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester and 4-chloromethyl-2-(3,5-dimethoxy-phenyl)-5-methyl-oxazole, the title compound was obtained in 43% yield as a pale red solid. MS: (M−H)− 463.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-3360ffa6993f4a00a9f941ae118da88f |
| Source note | uspto-grants-2005_05 |