4-(Chloromethyl)-2-phenyl-1,3-oxazole → HCID 10045901, compound

HRID 2181223Notes

Reaction equation

HRID 2181223 reaction equation
C([O:3][C:4](=[O:19])[CH:5]([O:16][CH2:17][CH3:18])[CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[CH:10]2)C.Cl[CH2:21][C:22]1[N:23]=[C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[O:25][CH:26]=1>>[CH2:17]([O:16][CH:5]([CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH2:21][C:22]1[N:23]=[C:24]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[O:25][CH:26]=1)[CH:11]=[CH:10]2)[C:4]([OH:3])=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 35511964-(Chloromethyl)-2-phenyl-1,3-oxazoleHCID 69563293Rac-2-ethoxy-3-(1h-indol-5-yl)-propionic acid ethyl ester

Product 1

HCID 10045901HCID 10045901, compoundYield 80%

Procedure

Starting from rac-2-ethoxy-3-(1H-indol-5-yl)-propionic acid ethyl ester and 4-chloromethyl-2-phenyl-oxazole, the title compound was obtained in 80% yield as a brown oil. MS: (M+H)+ 391.1.

Sources & evidence

ORD record
ord-3c42431283ba48db81fb805ccd3b120d
Source dataset
uspto-grants-2005_05
Patent number
US06890947B2

Reaction notes

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