2-(4-Trifluoromethylphenyl)-4-chloromethyl-5-methyloxazole → 2-Propoxypropanoic acid

HRID 2181239Notes

Reaction equation

HRID 2181239 reaction equation
C[O:2][C:3](=[O:19])[CH:4]([O:15][CH2:16][CH2:17][CH3:18])[CH2:5]C1C=C2C(=CC=1)NC=C2.ClCC1N=C(C2C=CC(C(F)(F)F)=CC=2)OC=1C>>[CH2:16]([O:15][CH:4]([CH3:5])[C:3]([OH:19])=[O:2])[CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 102363332-(4-Trifluoromethylphenyl)-4-chloromethyl-5-methyloxazoleHCID 69562937Methyl α-propoxy-1H-indole-5-propanoate

Product 1

HCID 144955462-Propoxypropanoic acid

Procedure

In analogy to the procedure described in example 44, rac-3-(1H-indol-5-yl)-2-propoxy-propionic acid methyl ester (preparation 6) was reacted with 4-chloromethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole to give rac-3-1-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl methyl]-1H-indol-5-yl}-2-propoxy-propionic acid as light yellow solid.

Sources & evidence

ORD record
ord-69050f0f31ab4c25a386ef72b9b664a6
Source dataset
uspto-grants-2005_05
Patent number
US06890947B2

Reaction notes

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