2-(4-Trifluoromethylphenyl)-4-chloromethyl-5-methyloxazole → Rac-3-{1-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl methyl]-1h-indol-5-yl}-2-phenoxy-propionic acid
Reaction equation
C[O:2][C:3](=[O:22])[CH:4]([O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[CH:9]2.Cl[CH2:24][C:25]1[N:26]=[C:27]([C:31]2[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][CH:32]=2)[O:28][C:29]=1[CH3:30]>>[CH3:30][C:29]1[O:28][C:27]([C:31]2[CH:32]=[CH:33][C:34]([C:37]([F:40])([F:38])[F:39])=[CH:35][CH:36]=2)=[N:26][C:25]=1[CH2:24][N:11]1[C:12]2[C:8](=[CH:7][C:6]([CH2:5][CH:4]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:3]([OH:2])=[O:22])=[CH:14][CH:13]=2)[CH:9]=[CH:10]1Participants
3
Procedure
In analogy to the procedure described in example 44, rac-3-(1H-indol-5-yl)-2-phenoxy-propionic acid methyl ester (preparation 7) was reacted with 4-chloromethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole to give rac-3-{1-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl methyl]-1H-indol-5-yl}-2-phenoxy-propionic acid as colorless solid.
Sources & evidence
- ORD record
- ord-0d6183ee1dda4524b3854f8a6afe3e3d
- Source dataset
- uspto-grants-2005_05
- Patent number
- US06890947B2
Reaction notes
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