HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Trifluoromethylphenyl)-4-chloromethyl-5-methyloxazole → Rac-3-{1-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl methyl]-1h-indol-5-yl}-2-phenoxy-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Trifluoromethylphenyl)-4-chloromethyl-5-methyloxazole | HCID 10236333 | — |
| Reactant | Rac-3-(1h-indol-5-yl)-2-phenoxy-propionic acid methyl ester | HCID 69563280 | — |
| Product | Rac-3-{1-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl methyl]-1h-indol-5-yl}-2-phenoxy-propionic acid | HCID 11756421 | — |
Reaction Steps
In analogy to the procedure described in example 44, rac-3-(1H-indol-5-yl)-2-phenoxy-propionic acid methyl ester (preparation 7) was reacted with 4-chloromethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole to give rac-3-{1-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl methyl]-1H-indol-5-yl}-2-phenoxy-propionic acid as colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-0d6183ee1dda4524b3854f8a6afe3e3d |
| Source note | uspto-grants-2005_05 |