4-(Chloromethyl)-2-(4-isopropylphenyl)-5-methyloxazole → Rac-3-{1-[2-(4-isopropyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1h-indol-5-yl}-2-phenoxy-propionic acid
Reaction equation
C[O:2][C:3](=[O:22])[CH:4]([O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[CH:9]2.Cl[CH2:24][C:25]1[N:26]=[C:27]([C:31]2[CH:36]=[CH:35][C:34]([CH:37]([CH3:39])[CH3:38])=[CH:33][CH:32]=2)[O:28][C:29]=1[CH3:30]>>[CH:37]([C:34]1[CH:33]=[CH:32][C:31]([C:27]2[O:28][C:29]([CH3:30])=[C:25]([CH2:24][N:11]3[C:12]4[C:8](=[CH:7][C:6]([CH2:5][CH:4]([O:15][C:16]5[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=5)[C:3]([OH:2])=[O:22])=[CH:14][CH:13]=4)[CH:9]=[CH:10]3)[N:26]=2)=[CH:36][CH:35]=1)([CH3:39])[CH3:38]Participants
3
Procedure
In analogy to the procedure described in example 44, rac-3-(1H-indol-5-yl)-2-phenoxy-propionic acid methyl ester (preparation 7) was reacted with 4-chloromethyl-2-(4-isopropyl-phenyl)-5-methyl-oxazole to give rac-3-{1-[2-(4-isopropyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-2-phenoxy-propionic acid as off-white solid.
Sources & evidence
- ORD record
- ord-2a742291bcc545c1b51db0e08c66db0e
- Source dataset
- uspto-grants-2005_05
- Patent number
- US06890947B2
Reaction notes
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