HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-(4-isopropylphenyl)-5-methyloxazole → Rac-3-{1-[2-(4-isopropyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1h-indol-5-yl}-2-phenoxy-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-(4-isopropylphenyl)-5-methyloxazole | HCID 21974255 | — |
| Reactant | Rac-3-(1h-indol-5-yl)-2-phenoxy-propionic acid methyl ester | HCID 69563280 | — |
| Product | Rac-3-{1-[2-(4-isopropyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1h-indol-5-yl}-2-phenoxy-propionic acid | HCID 10255192 | — |
Reaction Steps
In analogy to the procedure described in example 44, rac-3-(1H-indol-5-yl)-2-phenoxy-propionic acid methyl ester (preparation 7) was reacted with 4-chloromethyl-2-(4-isopropyl-phenyl)-5-methyl-oxazole to give rac-3-{1-[2-(4-isopropyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-2-phenoxy-propionic acid as off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-2a742291bcc545c1b51db0e08c66db0e |
| Source note | uspto-grants-2005_05 |