4-(Chloromethyl)-2-(2-chlorophenyl)-5-methyloxazole → HCID 11744618, compound

HRID 2181256Notes

Reaction equation

HRID 2181256 reaction equation
C([O:3][C:4](=[O:20])[CH:5]([O:17][CH2:18][CH3:19])[CH2:6][C:7]1[C:8]([CH3:16])=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[CH:10]2)C.Cl[CH2:22][C:23]1[N:24]=[C:25]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[Cl:35])[O:26][C:27]=1[CH3:28]>>[Cl:35][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=1[C:25]1[O:26][C:27]([CH3:28])=[C:23]([CH2:22][N:12]2[C:13]3[C:9](=[C:8]([CH3:16])[C:7]([CH2:6][CH:5]([O:17][CH2:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:15][CH:14]=3)[CH:10]=[CH:11]2)[N:24]=1

Participants

3

Reactant 2

HCID 219742564-(Chloromethyl)-2-(2-chlorophenyl)-5-methyloxazoleHCID 69563695Rac-2-ethoxy-3-(4-methyl-1h-indol-5-yl)-propionic acid ethyl ester

Product 1

HCID 11744618HCID 11744618, compound

Procedure

In analogy to the procedure described in example 44, rac-2-ethoxy-3-(4-methyl-1H-indol-5-yl)-propionic acid ethyl ester [preparation 10h)] was reacted with 4-chloromethyl-2-(2-chloro-phenyl)-5-methyl-oxazole to give rac-3-{1-[2-(2-chloro-phenyl)-5-methyl-oxazol-4-ylmethyl]-4-methyl-1H-indol-5-yl}-2-ethoxy-propionic acid as yellow solid.

Sources & evidence

ORD record
ord-fd5665782c0e4fe2859a8b6e17499435
Source dataset
uspto-grants-2005_05
Patent number
US06890947B2

Reaction notes

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