Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl- → HCID 11754816, Verbindung

HRID 2181257Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2181257
C([O:3][C:4](=[O:20])[CH:5]([O:17][CH2:18][CH3:19])[CH2:6][C:7]1[C:8]([CH3:16])=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[CH:10]2)C.Cl[CH2:22][C:23]1[N:24]=[C:25]([C:29]2[CH:34]=[C:33]([O:35][CH3:36])[CH:32]=[C:31]([O:37][CH3:38])[CH:30]=2)[O:26][C:27]=1[CH3:28]>>[CH3:38][O:37][C:31]1[CH:30]=[C:29]([C:25]2[O:26][C:27]([CH3:28])=[C:23]([CH2:22][N:12]3[C:13]4[C:9](=[C:8]([CH3:16])[C:7]([CH2:6][CH:5]([O:17][CH2:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:15][CH:14]=4)[CH:10]=[CH:11]3)[N:24]=2)[CH:34]=[C:33]([O:35][CH3:36])[CH:32]=1

Komponenten

3

Edukt 2

HCID 21974252Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl-HCID 69563695HCID 69563695, Verbindung

Produkt 1

HCID 11754816HCID 11754816, Verbindung

Versuchsvorschrift

In analogy to the procedure described in example 44, rac-2-ethoxy-3-(4-methyl-1H-indol-5-yl)-propionic acid ethyl ester [preparation 10h)] was reacted with 4-chloromethyl-2-(3,5-dimethoxy-phenyl)-5-methyl-oxazole to give rac-3-{1-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-4-methyl-1H-indol-5-yl}-2-ethoxy-propionic acid as yellow solid.

Quellen und Nachweise

ORD-Eintrag
ord-1070fe392b704f74b7c1d1fc1dcfdf23
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06890947B2

Notizen zur Reaktion

Wird geladen…