Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl- → Rac-3-{1-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1h-indol-6-yl}-2-ethoxy-propionic acid
Reaction equation
C([O:3][C:4](=[O:19])[CH:5]([O:16][CH2:17][CH3:18])[CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH:11]=[CH:12][NH:13]2)=[CH:9][CH:8]=1)C.Cl[CH2:21][C:22]1[N:23]=[C:24]([C:28]2[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[C:30]([O:36][CH3:37])[CH:29]=2)[O:25][C:26]=1[CH3:27]>>[CH3:37][O:36][C:30]1[CH:29]=[C:28]([C:24]2[O:25][C:26]([CH3:27])=[C:22]([CH2:21][N:13]3[C:14]4[C:10](=[CH:9][CH:8]=[C:7]([CH2:6][CH:5]([O:16][CH2:17][CH3:18])[C:4]([OH:3])=[O:19])[CH:15]=4)[CH:11]=[CH:12]3)[N:23]=2)[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=1Participants
3
Procedure
In analogy to the procedure described in example 44, rac-2-ethoxy-3-(1H-indol-6-yl)-propionic acid ethyl ester (preparation 11) was reacted with 4-chloromethyl-2-(3,5-dimethoxy-phenyl)-5-methyl-oxazole to give rac-3-{1-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-6-yl}-2-ethoxy-propionic acid as yellow solid.
Sources & evidence
- ORD record
- ord-baadcf5750884d2e9f25a8e8428fe426
- Source dataset
- uspto-grants-2005_05
- Patent number
- US06890947B2
Reaction notes
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