Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl- → Rac-3-{1-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1h-indol-6-yl}-2-ethoxy-propionic acid

Participants

Reaction Steps

In analogy to the procedure described in example 44, rac-2-ethoxy-3-(1H-indol-6-yl)-propionic acid ethyl ester (preparation 11) was reacted with 4-chloromethyl-2-(3,5-dimethoxy-phenyl)-5-methyl-oxazole to give rac-3-{1-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-6-yl}-2-ethoxy-propionic acid as yellow solid.

Provenance & Evidence