Hydrochloric Acid → HCID 22485743, compound

Participants

Reaction Steps

5.00 g (4RS,5RS)-4-dimethylaminomethyl-5-(3-methoxybenzyl)-2,3,4,5-tetrahydro-benzo[b]thiepin-5-ol (see example 9) were reacted with 230 ml 6N hydrochloric acid by the procedure described in example 13. After processing, separation of the double bond isomers by column chromatography with ethyl acetate/methanol=3/1 and conversion into the hydrochloride, the title compounds were obtained in the form of white crystals.

Provenance & Evidence