Hydrochloric Acid → HCID 22485743, compound

HRID 2181285Notes

Reaction equation

[CH3:1][N:2]([CH2:4][CH:5]1[CH2:11][CH2:10][S:9][C:8]2[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=2[C:6]1([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=1)O)[CH3:3].[ClH:26]>>[ClH:26].[CH3:25][O:24][C:20]1[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=1)/[CH:17]=[C:6]1/[C:7]2[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=2[S:9][CH2:10][CH2:11][CH:5]/1[CH2:4][N:2]([CH3:3])[CH3:1]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 22485741HCID 22485741, compound

Product 1

HCID 22485743HCID 22485743, compound

Procedure

5.00 g (4RS,5RS)-4-dimethylaminomethyl-5-(3-methoxybenzyl)-2,3,4,5-tetrahydro-benzo[b]thiepin-5-ol (see example 9) were reacted with 230 ml 6N hydrochloric acid by the procedure described in example 13. After processing, separation of the double bond isomers by column chromatography with ethyl acetate/methanol=3/1 and conversion into the hydrochloride, the title compounds were obtained in the form of white crystals.

Workup

customseparation of the double bond isomers by column chromatography with ethyl acetate/methanol=3/1 and conversion into the hydrochloride

Sources & evidence

ORD record: ord-d63efd3ee3294734a5db2722f43d55b1
Source dataset: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06890952B2

Reaction notes

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