Hydrochloric Acid → 3,5-Dimethoxy-4-(2,2,2-trifluoroethoxy)aniline hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Methanol	HCID 887	—
Reactant	N-t-butoxycarbonyl-3,5-dimethoxy-4-(2,2,2-trifluoroethoxy)aniline	HCID 22485510	—
Product	3,5-Dimethoxy-4-(2,2,2-trifluoroethoxy)aniline hydrochloride	HCID 22485529	—

Reaction Conditions

Temperature	50 °C

Reaction Steps

N-t-butoxycarbonyl-3,5-dimethoxy-4-(2,2,2-trifluoroethoxy)aniline (1.10 g, 3.13 mmol) was added to a 10% solution of hydrogen chloride in methanol (20 mL, 55 mmol), and the resulting solution was stirred at 50° C. for 30 minutes. The reaction mixture was concentrated under reduced pressure to give crude 3,5-dimethoxy-4-(2,2,2-trifluoroethoxy)aniline hydrochloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06890940B2
Source dataset	uspto-grants-2005_05
ORD ID	ord-e83b414d5a9c4a6e9a9fb725b6ffff82
Source note	uspto-grants-2005_05