1-Iodo-3,5-dimethoxy-4-(2,2,2-trifluoroethoxy)benzene → 3,5-Dimethoxy-4-(2,2,2-trifluoroethoxy)phenylboronic acid

HRID 2181293Notes

Reaction equation

HRID 2181293 reaction equation
C(OC1C(OC)=CC([B:12]([OH:14])[OH:13])=CC=1OC)C.C(OC1C(OC)=CC(I)=CC=1OC)C.I[C:32]1[CH:37]=[C:36]([O:38][CH3:39])[C:35]([O:40][CH2:41][C:42]([F:45])([F:44])[F:43])=[C:34]([O:46][CH3:47])[CH:33]=1>>[CH3:47][O:46][C:34]1[CH:33]=[C:32]([B:12]([OH:14])[OH:13])[CH:37]=[C:36]([O:38][CH3:39])[C:35]=1[O:40][CH2:41][C:42]([F:45])([F:44])[F:43]

Participants

4

Reactant 3

HCID 224855031-Iodo-3,5-dimethoxy-4-(2,2,2-trifluoroethoxy)benzeneHCID 22485535(4-Ethoxy-3,5-dimethoxyphenyl)boronic acidHCID 224855594-Ethoxy-1-iodo-3,5-dimethoxybenzene

Product 1

HCID 224855543,5-Dimethoxy-4-(2,2,2-trifluoroethoxy)phenylboronic acid

Procedure

Applying the synthetic procedure of 4-ethoxy-3,5-dimethoxyphenylboronic acid from 4-ethoxy-1-iodo-3,5-dimethoxybenzene in Reference Example 3, the title compound was prepared as a colorless amorphous powder (369.0 mg, yield: 48%) from 1-iodo-3,5-dimethoxy-4-(2,2,2-trifluoroethoxy)-benzene (1.00 g, 2.76 mmol).

Sources & evidence

ORD record
ord-96250e428b2b42cb9d0d8e29b45cd7a6
Source dataset
uspto-grants-2005_05
Patent number
US06890940B2

Reaction notes

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