HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-3-buten-2-ol → 5-[3-Hydroxy-3-methyl-1-butenyl]-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-3-buten-2-ol | HCID 8257 | — |
| Reactant | 5-Bromo-1-isobutyl-3-methyl-6-[2-(trifluoromethyl)benzyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione | HCID 11442902 | — |
| Product | 5-[3-Hydroxy-3-methyl-1-butenyl]-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione | HCID 69746621 | — |
Reaction Steps
Prepared using 5-bromo-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione and 2-methyl-3-buten-2-ol. The crude product was purified by flash silica chromatography eluting with a gradient of 0-2% ethanol in dichloromethane to give the title compound as a cream foam (0.20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890923B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-96ee60cbe7ac41d49640a0f0fe1b1e34 |
| Source note | uspto-grants-2005_05 |