HuagongsheHuagongshe Chemistry Print Report · For research reference only
Vinylcyclopentane → (Z)-5-[2-cyclopentylethenyl]-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Vinylcyclopentane | HCID 77345 | — |
| Reactant | 5-Bromo-1-isobutyl-3-methyl-6-[2-(trifluoromethyl)benzyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione | HCID 11442902 | — |
| Product | (Z)-5-[2-cyclopentylethenyl]-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione | HCID 69747927 | — |
Reaction Steps
Prepared using 5-bromo-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione and cyclopentyl-ethene. The crude product was purified by flash silica chromatography eluting with a gradient of 5-20% ethanol in dichloromethane to give the title compound as a yellow oil (0.17 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890923B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-d511b31787344f8b89b4c6ae9c4185cf |
| Source note | uspto-grants-2005_05 |