反应详情

5-Bromo-1-isobutyl-3-methyl-6-[2-(trifluoromethyl)benzyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (Example 1 part c)) (100 mg) was dissolved in tetrahydrofuran (2 mls) and EtMgBr (250 ul of 1M solution in tetrahydrofuran) was added. After 10 mins 2-fluorobenzaldehyde (250 ul of a 1M solution in tetrahydrofuran) was added. After 1 hr the reaction was quenched via addition of water. The reaction was concentrated in vacuo and extracted into dichloromethane, concentrated in vacuo and the residue purified via chromatography eluting with 0-100% diethyl ether in isohexane to yield the title compound (9 mg).

1. customAfter 1 hr the reaction was quenched via addition of water
2. concentrationThe reaction was concentrated in vacuo
3. extractionextracted into dichloromethane
4. concentrationconcentrated in vacuo
5. customthe residue purified via chromatography
6. washeluting with 0-100% diethyl ether in isohexane