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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2181474Generated: October 27, 2026

1,1'-Carbonyldiimidazole → 3,4-Difluoro-2-[[2-fluoro-4-(ethylthio)phenyl]amino]-N-(2-hydroxyethoxy)benzamide

https://huagongshe.com/reaction/2181474

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-CarbonyldiimidazoleHCID 68263—
ReactantEthanol, 2-(aminooxy)-HCID 3014186—
Reactant3,4-Difluoro-2-[[2-fluoro-4-(ethylthio)phenyl]amino]benzoic acidHCID 22025691—
Product3,4-Difluoro-2-[[2-fluoro-4-(ethylthio)phenyl]amino]-N-(2-hydroxyethoxy)benzamideHCID 10194063—

Reaction Steps

The title compound was prepared from reaction of the product of Example 27, Step B, 3,4-difluoro-2-[[2-fluoro-4-(ethylthio)phenyl]amino]benzoic acid with CDI and 2-(aminooxy)ethanol by the general procedure of Example 1,

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06891066B2
Source datasetuspto-grants-2005_05
ORD IDord-4e4d4ef1106e47a982e85db929a15845
Source noteuspto-grants-2005_05