1,1'-Carbonyldiimidazole → 3,4-Difluoro-2-[[2-fluoro-4-(ethylthio)phenyl]amino]-N-(2-hydroxyethoxy)benzamide

HRID 2181474Notes

Reaction equation

HRID 2181474 reaction equation
[F:1][C:2]1[C:3]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([S:19][CH2:20][CH3:21])=[CH:15][C:14]=2[F:22])=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([OH:7])=O.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:35][O:36][CH2:37][CH2:38][OH:39]>>[F:1][C:2]1[C:3]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([S:19][CH2:20][CH3:21])=[CH:15][C:14]=2[F:22])=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([NH:35][O:36][CH2:37][CH2:38][OH:39])=[O:7]

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 3014186Ethanol, 2-(aminooxy)-HCID 220256913,4-Difluoro-2-[[2-fluoro-4-(ethylthio)phenyl]amino]benzoic acid

Product 1

HCID 101940633,4-Difluoro-2-[[2-fluoro-4-(ethylthio)phenyl]amino]-N-(2-hydroxyethoxy)benzamide

Procedure

The title compound was prepared from reaction of the product of Example 27, Step B, 3,4-difluoro-2-[[2-fluoro-4-(ethylthio)phenyl]amino]benzoic acid with CDI and 2-(aminooxy)ethanol by the general procedure of Example 1,

Sources & evidence

ORD record
ord-4e4d4ef1106e47a982e85db929a15845
Source dataset
uspto-grants-2005_05
Patent number
US06891066B2

Reaction notes

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