反应详情

温度

130 °C

A mixture of 3-trifluoromethylbenzyl mercaptan (3.42 g), diisopropylethylamine (2.3 g) and 3-chloro-6-nitro-p-xylene (3.0 g) in dry N-methylpyrrolidinone (20 ml) was heated at 130° C. for 6 hours. On cooling, the mixture was poured into ice-water and the resulting mixture was filtered to give a solid which was washed with ice-water and then air dried. The solid was purified by silica gel chromatography eluting with light petroleum (60-80° C.)/ethyl acetate (9:1) to give the title product as a solid, m.p. 85-7° C.

1. temperatureOn cooling
2. filtrationthe resulting mixture was filtered
3. customto give a solid which
4. washwas washed with ice-water
5. customair dried
6. customThe solid was purified by silica gel chromatography
7. washeluting with light petroleum (60-80° C.)/ethyl acetate (9:1)