Hydrochloric Acid → HCID 22481224, compound

HRID 2181588Notes

Reaction equation

HRID 2181588 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([C:9]2[C:14]([CH3:15])=[CH:13][C:12]([NH:16]C(=O)C(C)(C)C)=[C:11]([CH3:23])[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.Cl.O>C(O)(=O)C>[F:1][C:2]([F:24])([F:25])[C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([CH3:23])[C:12](=[CH:13][C:14]=2[CH3:15])[NH2:16])[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 22481235HCID 22481235, compound

Product 1

HCID 22481224HCID 22481224, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

The product from stage b) (10.4 g) in glacial acetic acid (36 ml) was treated with hydrochloric acid (24.5 ml of 15% solution) at 70° C. The mixture was stirred for 3 days at 100° C. On cooling, water was added and the mixture extracted with ethyl acetate. The organic phase was washed with sodium bicarbonate solution, dried (MgSO4) and concentrated to give the title product.

Workup

  1. temperatureOn cooling
  2. extractionthe mixture extracted with ethyl acetate
  3. washThe organic phase was washed with sodium bicarbonate solution
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-7e2dfb6642f64a8190ec413c110413e4
Source dataset
uspto-grants-2005_05
Patent number
US06893650B1

Reaction notes

Loading…