HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 22481230, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzo(B)Thiophene-2-Boronic Acid | HCID 2359 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Bromo-2,5-dimethyl-4-nitrobenzene | HCID 825808 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 22481230 | HCID 22481230 | — |
Reaction Steps
A mixture of 2-bromo-5-nitro-p-xylene (200 g), 2-benzo[b]thiopheneboronic acid (200 g), (Ph3P)4Pd (0.36 g) in toluene (60 ml) and ethanol (22 ml) was heated to reflux overnight. Ethyl acetate and water were added and the organic phase was separated. The organic phase was washed with water, dried (MgSO4) and filtered through a pad of silica to give the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06893650B1 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-b3ea34a2a49448b1868cb32b9b2f5b0b |
| Source note | uspto-grants-2005_05 |