2,2,2-Trifluoroethanesulfonyl chloride → HCID 59251192, compound

HRID 218161Notes

Reaction equation

HRID 218161 reaction equation
[OH:1][C:2]([C:4]([F:7])([F:6])[F:5])=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:23]3[C:18](=[CH:19][C:20]([CH:24]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH2:25][CH2:26][NH2:27])=[CH:21][CH:22]=3)[CH:17]=[N:16]2)=[CH:11][CH:10]=1.FC(F)(F)CS(Cl)(=O)=O>>[F:5][C:4]([F:7])([F:6])[C:2]([NH:27][CH2:26][CH2:25][CH:24]([C:20]1[CH:19]=[C:18]2[C:23](=[CH:22][CH:21]=1)[N:15]([C:12]1[CH:11]=[CH:10][C:9]([F:8])=[CH:14][CH:13]=1)[N:16]=[CH:17]2)[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)=[O:1]

Participants

3

Reactant 2

HCID 742422,2,2-Trifluoroethanesulfonyl chlorideHCID 86640192HCID 86640192, compound

Product 1

HCID 59251192HCID 59251192, compoundYield 99.7%

Procedure

Prepared from 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropan-1-amine TFA salt (25 mg, 0.05 mmol) by adding 2,2,2-trifluoroethanesulfonyl chloride under the General Coupling Method B conditions. Obtained 22 mg (82%) of 2,2,2-trifluoro-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropyl)acetamide. MS found: (M+H)+=442.

Sources & evidence

ORD record
ord-a01969a549c042219f0cc70650620c13
Source dataset
uspto-grants-2012_06
Patent number
US08198311B2

Reaction notes

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