反应详情

The title compound was prepared from N-(4′-fluoro-1,1′-biphenyl-2-yl)propanamide (5.00 g, 20.6 mmol) and phosphorous oxychloride (9.6 mL, 103 mmol), according to the procedure and in the same manner as described in Example 36, Step b to yield, after purification by re-crystallization from a mixture of ethyl acetate-hexane, 6-ethyl-8-fluorophenanthridine as a white solid (1.43 g, 31%, m.p. 105-106° C.;

1. customto yield
2. customafter purification
3. customby re-crystallization
4. additionfrom a mixture of ethyl acetate-hexane, 6-ethyl-8-fluorophenanthridine as a white solid (1.43 g, 31%, m.p. 105-106° C.