Phosphorus oxychloride → HCID 22482260, compound

HRID 2181833Notes

Reaction equation

HRID 2181833 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:14][C:15](=O)[CH2:16][CH3:17])=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>>[CH2:16]([C:15]1[N:14]=[C:9]2[C:8](=[C:5]3[C:6]=1[CH:7]=[C:2]([F:1])[CH:3]=[CH:4]3)[CH:13]=[CH:12][CH:11]=[CH:10]2)[CH3:17]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 22482275HCID 22482275, compound

Product 1

HCID 22482260HCID 22482260, compound

Procedure

The title compound was prepared from N-(4′-fluoro-1,1′-biphenyl-2-yl)propanamide (5.00 g, 20.6 mmol) and phosphorous oxychloride (9.6 mL, 103 mmol), according to the procedure and in the same manner as described in Example 36, Step b to yield, after purification by re-crystallization from a mixture of ethyl acetate-hexane, 6-ethyl-8-fluorophenanthridine as a white solid (1.43 g, 31%, m.p. 105-106° C.;

Workup

  1. customto yield
  2. customafter purification
  3. customby re-crystallization
  4. additionfrom a mixture of ethyl acetate-hexane, 6-ethyl-8-fluorophenanthridine as a white solid (1.43 g, 31%, m.p. 105-106° C.

Sources & evidence

ORD record
ord-6da2bb54d95b45a5b9afab7971a18c04
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Reaction notes

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