Ammonium Acetate → 1-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

HRID 2181908ノート

反応式

HRID 2181908 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16](=O)[CH3:17].C([O-])(=O)C.[NH4+].C([BH3-])#[N:25].[Na+]>CO>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH:16]([NH2:25])[CH3:17]

参加物

5

反応物 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 224823721-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethanone

生成物 1

HCID 224823821-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The title compound was prepared from 1-(2′,4′,5-trifluoro-1,1′-biphenyl-2-yl)ethanone (720 mg, 2.9 mmol), anhydrous methanol (10 mL), ammonium acetate (4.44 g, 58 mmol), and sodium cyanoborohydride (362 g, 5.8 mmol) according to the procedure and in the same manner as described in Example 105, step b. The crude amine was immediately used without further purification in Example 114, step c;

後処理

  1. customThe crude amine was immediately used without further purification in Example 114, step c

出典と根拠

ORDレコード
ord-aedbfb1c67b5452db02693817d12d88e
出典データセット
uspto-grants-2005_05
特許番号
US06894061B2

反応ノート

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