4-Methoxybenzenesulfonyl chloride → N-[1-(4'-Chloro-2'-fluoro-1,1'-biphenyl-2-yl)ethyl]-4-methoxybenzenesulfonamide

Participants

Reaction Steps

The title compound was prepared from 4-methoxybenzenesulfonyl chloride (331 mg, 1.6 mmol), 1-(4′chloro-2′-fluoro-1,1′-biphenyl-2-yl)ethylamine (400 mg, 1.6 mmol), and triethylamine (246 μL, 1.7 mmol) according to the procedure and in the same manner as described in Example 105, step c resulting in the isolation of 644 mg (96%) of a white solid;

Provenance & Evidence