4-Methoxybenzenesulfonyl chloride → N-[1-(4'-Chloro-2'-fluoro-1,1'-biphenyl-2-yl)ethyl]-4-methoxybenzenesulfonamide

HRID 2181930Notes

Reaction equation

HRID 2181930 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH:26]([NH2:28])[CH3:27])=[C:16]([F:29])[CH:15]=1.C(N(CC)CC)C>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH:26]([NH:28][S:9]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)(=[O:11])=[O:10])[CH3:27])=[C:16]([F:29])[CH:15]=1

Participants

4

Reactant 3

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 8471TriethylamineHCID 224823611-(4'-Chloro-2'-fluoro-biphenyl-2-yl)-ethylamine

Product 1

HCID 22482270N-[1-(4'-Chloro-2'-fluoro-1,1'-biphenyl-2-yl)ethyl]-4-methoxybenzenesulfonamide

Procedure

The title compound was prepared from 4-methoxybenzenesulfonyl chloride (331 mg, 1.6 mmol), 1-(4′chloro-2′-fluoro-1,1′-biphenyl-2-yl)ethylamine (400 mg, 1.6 mmol), and triethylamine (246 μL, 1.7 mmol) according to the procedure and in the same manner as described in Example 105, step c resulting in the isolation of 644 mg (96%) of a white solid;

Sources & evidence

ORD record
ord-780d5ce8891e4a639237fe2e6028ab04
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Reaction notes

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