HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-Carbamoyl-1,2,3,6-tetrahydropyridine trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 4-carbamoyl-3,6-dihydropyridine-1(2H)-carboxylate | HCID 22482730 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-Carbamoyl-1,2,3,6-tetrahydropyridine trifluoroacetate | HCID 22482741 | — |
Reaction Steps
In 20 ml of chloroform, 3.7 g of 1-tert-butoxycarbonyl-4-carbamoyl-1,2,3,6-tetrahydropyridine was dissolved, and 13 ml of trifluoroacetic acid were added thereto. The reaction mixture was stirred for 1 hour at room temperature, and subsequently was concentrated under reduced pressure to yield 4.1 g of crude 4-carbamoyl-1,2,3,6-tetrahydropyridine trifluoroacetate as a crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06894168B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-bd0780fbc93845618b6d61e206a105ac |
| Source note | uspto-grants-2005_05 |