Trifluoroacetic acid → 4-Carbamoyl-1,2,3,6-tetrahydropyridine trifluoroacetate

HRID 2182058Notes

Reaction equation

HRID 2182058 reaction equation
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14](=[O:16])[NH2:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>C(Cl)(Cl)Cl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[C:14]([C:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=1)(=[O:16])[NH2:15]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22482730tert-Butyl 4-carbamoyl-3,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 224827414-Carbamoyl-1,2,3,6-tetrahydropyridine trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In 20 ml of chloroform, 3.7 g of 1-tert-butoxycarbonyl-4-carbamoyl-1,2,3,6-tetrahydropyridine was dissolved, and 13 ml of trifluoroacetic acid were added thereto. The reaction mixture was stirred for 1 hour at room temperature, and subsequently was concentrated under reduced pressure to yield 4.1 g of crude 4-carbamoyl-1,2,3,6-tetrahydropyridine trifluoroacetate as a crystal.

Workup

  1. concentrationsubsequently was concentrated under reduced pressure

Sources & evidence

ORD record
ord-bd0780fbc93845618b6d61e206a105ac
Source dataset
uspto-grants-2005_05
Patent number
US06894168B2

Reaction notes

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