HCID 22482739, compound → HCID 5252118, compound

HRID 2182059Notes

Reaction equation

HRID 2182059 reaction equation
Cl.[C:2]([C:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH:10]=1)(=[O:4])[NH2:3]>C(=O)([O-])O.[Na+]>[C:2]([C:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH:6]=1)(=[O:4])[NH2:3]

Participants

3

Reactant 1

HCID 22482739HCID 22482739, compound

Product 1

HCID 5252118HCID 5252118, compound

Reagents, catalysts & solvents 1

HCID 516892Sodium BicarbonateSolvent

Procedure

4-carbamoyl-1,2,3,6-tetrahydropyridine hydrochloride was dissolved in a saturated aqueous solution of sodium hydrogen carbonate, followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate. After the desiccant was filtered off, the filtrate was concentrated under reduced pressure to yield crystals of free 4-carbamoyl-1,2,3,6-tetrahydropyridine.

Workup

  1. extractionfollowed by extraction with chloroform
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. filtrationAfter the desiccant was filtered off
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0c3f8ac9ce474cb38cb7adf7662768cb
Source dataset
uspto-grants-2005_05
Patent number
US06894168B2

Reaction notes

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