Trifluoroacetic acid → HCID 22482749, compound

HRID 2182063Notes

Reaction equation

HRID 2182063 reaction equation
C(OC([N:8]1[CH2:13][C:12]([C:14](=[O:16])[NH2:15])=[CH:11][CH2:10][CH2:9]1)=O)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>C(Cl)(Cl)Cl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[C:14]([C:12]1[CH2:13][NH:8][CH2:9][CH2:10][CH:11]=1)(=[O:16])[NH2:15]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22482765HCID 22482765, compound

Product 1

HCID 22482749HCID 22482749, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In 4.0 ml of chloroform, 1.1 g of 1-tert-butoxycarbonyl-5-carbamoyl-1,2,3,6-tetrahydropyridine was dissolved, and 4.0 ml of trifluoroacetic acid was added thereto. The reaction mixture was stirred for 30 minutes at room temperature, and was subsequently concentrated under reduced pressure to yield 1.4 g of crude 5-carbamoyl-1,2,3,6-tetrahydropyridine trifluoroacetate in the form of amorphous.

Workup

  1. concentrationwas subsequently concentrated under reduced pressure

Sources & evidence

ORD record
ord-6eb1a84faa434024a49192a20390e8cb
Source dataset
uspto-grants-2005_05
Patent number
US06894168B2

Reaction notes

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