HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 22482956, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Methyl L-phenylalaninate hydrochloride | HCID 75736 | — |
| Reactant | Efaproxiral | HCID 122335 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22482956 | HCID 22482956 | — |
Reaction Steps
Using RSR13 acid (1.6 g, 4.7 mmol), phenylalanine methyl ester hydrochloride (1.08 mg, 4.7 mmol) and 1-hydroxybenzotriazole hydrate (697 mg, 5.2 mmol), N-methylmorpholine (711 mg, 7.0 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.08 g, 5.3 mmol) in dimethylformamide (40 mL), the two isomers were prepared in 2.2 g yield (96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06894185B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-68b8658489cd43b4bb67405c0c5da16c |
| Source note | uspto-grants-2005_05 |