4-Methylmorpholine → HCID 22482956, compound

HRID 2182126Notes

Reaction equation

HRID 2182126 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH3:25])[CH:5]=[C:6]([NH:8][C:9]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([O:18][C:19]([C:22]([OH:24])=O)([CH3:21])[CH3:20])=[CH:16][CH:17]=2)=[O:10])[CH:7]=1.Cl.C[O:28][C:29](=[O:39])[C@H:30]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[NH2:31].O.ON1C2C=CC=CC=2N=N1.CN1CCOCC1.Cl.CN(C)CCCN=C=NCC>CN(C)C=O>[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([O:18][C:19]([CH3:21])([CH3:20])[C:22]([NH:31][CH:30]([CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[C:29]([OH:39])=[O:28])=[O:24])=[CH:16][CH:17]=2)=[O:10])[CH:5]=[C:4]([CH3:25])[CH:3]=1

Participants

7

Reactant 5

HCID 79724-MethylmorpholineHCID 75736Methyl L-phenylalaninate hydrochlorideHCID 122335EfaproxiralHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrate

Product 1

HCID 22482956HCID 22482956, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using RSR13 acid (1.6 g, 4.7 mmol), phenylalanine methyl ester hydrochloride (1.08 mg, 4.7 mmol) and 1-hydroxybenzotriazole hydrate (697 mg, 5.2 mmol), N-methylmorpholine (711 mg, 7.0 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.08 g, 5.3 mmol) in dimethylformamide (40 mL), the two isomers were prepared in 2.2 g yield (96%).

Workup

  1. customthe two isomers were prepared in 2.2 g
  2. customyield (96%)

Sources & evidence

ORD record
ord-68b8658489cd43b4bb67405c0c5da16c
Source dataset
uspto-grants-2005_05
Patent number
US06894185B2

Reaction notes

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