Trifluoroacetic acid → HCID 9879509, compound

Participants

Reaction Steps

The title compound (2-A) was prepared from 6′-(3-chloro-benzylamino)-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-carboxylic acid tert-butyl ester (I-2b). To a solution of (I-2b) in CH2Cl2 was added trifluoroacetic acid. After stirring at room temperature for 3 h, the mixture was poured into 1N NaOH and extracted with CH2Cl2 (1×35 mL). The organic layer was washed with brine, dried and concentrated to afford the title compound as a free amine (2-A).

Provenance & Evidence