Trifluoroacetic acid → HCID 9879509, compound

HRID 2182134Notes

Reaction equation

HRID 2182134 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[N:18][CH:17]=[C:16]([NH:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O.[OH-].[Na+]>C(Cl)Cl>[Cl:28][C:24]1[CH:23]=[C:22]([CH:27]=[CH:26][CH:25]=1)[CH2:21][NH:20][C:16]1[N:15]=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:19]=[N:18][CH:17]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 69732326HCID 69732326, compound

Product 1

HCID 9879509HCID 9879509, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound (2-A) was prepared from 6′-(3-chloro-benzylamino)-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-carboxylic acid tert-butyl ester (I-2b). To a solution of (I-2b) in CH2Cl2 was added trifluoroacetic acid. After stirring at room temperature for 3 h, the mixture was poured into 1N NaOH and extracted with CH2Cl2 (1×35 mL). The organic layer was washed with brine, dried and concentrated to afford the title compound as a free amine (2-A).

Workup

  1. extractionextracted with CH2Cl2 (1×35 mL)
  2. washThe organic layer was washed with brine
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-5b087a06f9c34f21964786ffdde61624
Source dataset
uspto-grants-2005_05
Patent number
US06894050B2

Reaction notes

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