HCID 86588635, compound → HCID 22482058, compound

HRID 2182155Notes

Reaction equation

HRID 2182155 reaction equation
C([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[N:18][C:17]([Br:20])=[C:16]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=3)[N:15]=2)[CH2:10][CH2:9]1)=[O:7])(C)(C)C>C(O)=O>[CH:6]([OH:7])=[O:5].[Br:20][C:17]1[N:18]=[CH:19][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:15][C:16]=1[O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=1

Participants

3

Reactant 1

HCID 86588635HCID 86588635, compound

Product 1

HCID 22482058HCID 22482058, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of 5′-bromo-6′-(3-chloro-benzyloxy)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-4-carboxylic acid tert-butyl ester I-3j (25 mg, 0.052 mmol) in formic acid (96%, 0.75 ml) was stirred at room temperature for 2 h, and concentrated in vacuo. The title compound 3-R was collected as a white solid (26 mg, >99%).

Workup

  1. concentrationconcentrated in vacuo
  2. customThe title compound 3-R was collected as a white solid (26 mg, >99%)

Sources & evidence

ORD record
ord-9a652b6ab6fa426e817e3ea7ec8e3c6d
Source dataset
uspto-grants-2005_05
Patent number
US06894050B2

Reaction notes

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