Trifluoroacetic acid → HCID 9943787, compound

HRID 2182159Notes

Reaction equation

HRID 2182159 reaction equation
C(OC(=O)[N:7]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[CH:22]=1)[C:8]1[N:13]=[C:12]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH:11]=[N:10][CH:9]=1)(C)(C)C.FC(F)(F)C(O)=O.[OH-].[Na+]>C(Cl)Cl>[F:27][C:23]1[CH:22]=[C:21]([CH:26]=[CH:25][CH:24]=1)[CH2:20][NH:7][C:8]1[N:13]=[C:12]([N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[CH:11]=[N:10][CH:9]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 69732631HCID 69732631, compound

Product 1

HCID 9943787HCID 9943787, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (3-fluoro-benzyl)-(3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-6′-yl)-carbamic acid tert-butyl ester I-4c (30 mg, 0.08 mmol) in CH2Cl2 (1 mL) was added with trifluoroacetic Acid (0.5 mL) and the resulting mixture was stirred at ambient temperature for 19 h. The reaction mixture was poured into 1N NaOH (10 mL) and extracted with ethyl acetate (1×40 mL). The organic layer was washed with brine, dried (Na2SO4), and concentrated to give the title compound 4-A (19.3 mg).

Workup

  1. extractionextracted with ethyl acetate (1×40 mL)
  2. washThe organic layer was washed with brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-5c2c35974b50485b854fa2850aeb506d
Source dataset
uspto-grants-2005_05
Patent number
US06894050B2

Reaction notes

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