Trifluoroacetic acid → HCID 22482008, compound

HRID 2182167Notes

Reaction equation

HRID 2182167 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[N:18][CH:17]=[C:16]([N:20]([CH3:29])[CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[N:23]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[CH3:29][N:20]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[N:23]=1)[C:16]1[N:15]=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:19]=[N:18][CH:17]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69730740HCID 69730740, compound

Product 1

HCID 22482008HCID 22482008, compound

Procedure

6′-[Methyl-(6-methyl-pyridin-2-ylmethyl)-amino]-2,3,5,6-tetrahydro-[1,2′]-bipyrazinyl-4-carboxylic acid tert-butyl ester I-4g was deprotected with TFA as the procedure described in Example 4-A to afford the title compound 4-Q.

Sources & evidence

ORD record
ord-c5ede927eaa0470dafa2f7c41e1563fb
Source dataset
uspto-grants-2005_05
Patent number
US06894050B2

Reaction notes

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