反应详情

A solution of 6-chloro-pyrazin-2-ylamine (50 mg, 0.38 mmol) in acetic acid (1.9 mL) was treated with acetic anhydride (0.04 mL, 0.42 mmol). The mixture was heated to reflux for 1 h, cooled to room temperature, then poured into saturated NaHCO3 (30 mL) and extracted with ethyl acetate (2×30 mL). The organic layers were combined, washed with brine, dried (Na2SO4), filtered, and concentrated to dryness to give the title compound I-5a (58.6 mg).

1. temperatureThe mixture was heated
2. temperatureto reflux for 1 h
3. extractionextracted with ethyl acetate (2×30 mL)
4. washwashed with brine
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated to dryness