反应详情

A mixture of N-(6-chloro-pyrazin-2-yl)-acetamide I-5a (58.6 mg, 0.34 mmol) and piperazine-1-carboxylic acid tert-butyl ester (636 mg, 3.42 mmol) in ethanol (2 mL) was stirred at reflux for 24 h. The reaction mixture was diluted with ethyl acetate (40 mL) and washed with 0.1M HCl (3×35 mL), brine, dried (Na2SO4), filtered, and evaporated to dryness. The crude residue was purified by preparative TLC using ethyl acetate as the eluant to afford the title compound I-5b (36.9 mg).

1. temperatureat reflux for 24 h
2. washwashed with 0.1M HCl (3×35 mL), brine
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. customevaporated to dryness
6. customThe crude residue was purified by preparative TLC