HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → HCID 86591418, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 22477497 | HCID 22477497 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86591418 | HCID 86591418 | — |
Reaction Steps
A mixture of [2-(1H-pyrrolo[2,3-b]pyridin-2-yl)-pyrrol-1-yl]-acetic acid [10 mg, Example 54] and 2-(1H-benzotriazole-1-yl)1,1,3,3-tetramethyluronium hexafluorophosphate (15.7 mg) in dry dimethylformamide (0.2 mL) was agitated for 1 hour then treated with cyclopropylamine (5.68 μL) and diisopropylethylamine (7.16 μL) in dry dimethylformamide (0.226 mL). After agitating for a further 15 hours the crude mixture was subjected to LC-MS triggered purification affording the title compound. LC-MS: METHOD C: RT=2.44 minutes, 281[M+H]+ and 224(fragment corresponding to the breaking of the amide bond).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06897207B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-d788896e9ad84ca7818ff36b91fb3d95 |
| Source note | uspto-grants-2005_05 |