反应详情

A mixture of [2-(1H-pyrrolo[2,3-b]pyridin-2-yl)-pyrrol-1-yl]-acetic acid [10 mg, Example 54] and 2-(1H-benzotriazole-1-yl)1,1,3,3-tetramethyluronium hexafluorophosphate (15.7 mg) in dry dimethylformamide (0.2 mL) was agitated for 1 hour then treated with cyclopropylamine (5.68 μL) and diisopropylethylamine (7.16 μL) in dry dimethylformamide (0.226 mL). After agitating for a further 15 hours the crude mixture was subjected to LC-MS triggered purification affording the title compound. LC-MS: METHOD C: RT=2.44 minutes, 281[M+H]+ and 224(fragment corresponding to the breaking of the amide bond).

1. custompurification