反应详情

To a solution of the product of Example 22A (3.7 g, 13.6 mmoles) in tetrahydrofuran (110.0 ml) and methanol (37.0 ml) was added 2 N sodium hydroxide (19.0 ml) and the solution was stirred at ambient temperature for about 16 hours. The reaction mixture was concentrated in vacuum down to the water layer, was cooled with an ice bath, and was acidified by addition of 2N hydrochloric acid. The precipitate was filtered off and was dried in vacuum to provide the title compound.

1. concentrationThe reaction mixture was concentrated in vacuum down to the water layer
2. temperaturewas cooled with an ice bath
3. additionwas acidified by addition of 2N hydrochloric acid
4. filtrationThe precipitate was filtered off
5. customwas dried in vacuum