Ethyl 2-(4-bromophenyl)-2-methylpropanoate → 2-Methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)phenyl)propanoic acid

HRID 218226Notes

Reaction equation

HRID 218226 reaction equation
[CH3:1][C:2]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][N:16]=2)=[CH:11][CH:10]=1)([CH3:8])[C:3]([O:5]CC)=[O:4].BrC1C=CC(C(C)(C)C(OCC)=O)=CC=1>>[CH3:8][C:2]([C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:17][N:16]=2)=[CH:13][CH:14]=1)([CH3:1])[C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 11277257Ethyl 2-(4-bromophenyl)-2-methylpropanoateHCID 21099802Ethyl 2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)phenyl)propanoate

Product 1

HCID 210997162-Methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)phenyl)propanoic acid

Procedure

The title compound was prepared according to the method of Example 22B, substituting the product of Example 26B for the product of Example 22A.

Sources & evidence

ORD record
ord-2aef6b1798724533bf088b2ab16de01a
Source dataset
uspto-grants-2012_06
Patent number
US08198331B2

Reaction notes

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