Trifluoroacetic acid → HCID 178469925, compound

HRID 2182413Notes

Reaction equation

HRID 2182413 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH2:11][O:12]C(C)(C)C)=[N:8][NH:9][CH:10]=1)=[O:5])[CH3:2].FC(F)(F)C(O)=O>ClCCl>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH2:11][OH:12])=[N:8][NH:9][CH:10]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178469926HCID 178469926, compound

Product 1

HCID 178469925HCID 178469925, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 3-tert-butyloxymethyl-1H-pyrazole-4-carboxylic acid ethyl ester [3.46 g, Reference Example 42] in dichloromethane (25 ml) was treated with trifluoroacetic acid (25 ml). The mixture was stirred for 1.5 hours and then concentrated. The residue was partitioned between saturated sodium carbonate solution and ethyl acetate. The organic layer was dried over magnesium sulfate and then evaporated to give 3-hydroxymethyl-1H-pyrazole-4-carboxylic acid ethyl ester (2.49 g) as a brown solid which was used without further purification. LC-MS (METHOD B): RT=2.54 minutes; 171 (M+H)+. (b) 3-Hydroxymethyl-1H-pyrazole-4-carboxylic acid isopropylamide

Workup

  1. concentrationconcentrated
  2. customThe residue was partitioned between saturated sodium carbonate solution and ethyl acetate
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-590df456c6274dadb65f63a04ba3636e
Source dataset
uspto-grants-2005_05
Patent number
US06897208B2

Reaction notes

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