Ethylene Glycol → HCID 22480359, compound

HRID 2182501Notes

Reaction equation

HRID 2182501 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[O:18][C:19]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:20][CH:21]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)C[OH:29]>>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[O:18][C:19]([C:22]([O:24][CH2:25][CH2:26][OH:29])=[O:23])=[CH:20][CH:21]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 174Ethylene GlycolHCID 15408136HCID 15408136, compound

Product 1

HCID 22480359HCID 22480359, compound

Procedure

200 mg (0.6 mmol) of 1-benzyl-3-(5-ethoxycarbonyl-2-furyl)indazole were dissolved in ethylene glycol and heated under reflux for 1.5 h. For work-up, the mixture was concentrated using a rotary evaporator and the crude product was chromatographed over silica gel using hexane/ethyl acetate (1:1). This gave 68 mg (31%) of the title compound.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 1.5 h
  3. concentrationFor work-up, the mixture was concentrated
  4. customa rotary evaporator
  5. customthe crude product was chromatographed over silica gel

Sources & evidence

ORD record
ord-274786430a4441f3b6bbd602bdcc8918
Source dataset
uspto-grants-2005_05
Patent number
US06897232B2

Reaction notes

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